12/29/2023 0 Comments Extracellular fluid consists ofProblems that can be difficult to diagnose when changes in the ground substance are not visible on X-ray, MRI, ultrasound etc. The composition and change in the ECM and the ground substance and, among other things, the rapid change in the molecular composition of the hyaluronic acid are new insights that have given new knowledge about how the fascia affects the emergence of various types of problems, such as back pain, tennis elbow, frozen shoulder, neck pain and more. This is called mechanotransduction, as mechanical loading on cells is converted into a chemical response. The mechanical load on the ECM and thus the cells causes the cells to respond with producing various components, perhaps more collagen, and signaling proteins. Extracellular fluids bathe the cells and conduct. The extracellular fluid can be further divided into interstitial fluid, plasma, lymph, cerebrospinal fluid, and milk (in mammals). The composition adapts to the needs and requirements of the tissue. The fluids of the body may be classified into two main divisions: the fluid within cells (intracellular fluid) and the fluid outside the cell (extracellular fluid). The composition of the ECM and the proportions of the various components vary depending on the mechanical load to which the tissue cells are exposed. The components of the ECM are produced from different cells in the connective tissue. Link proteins also help to bind protein chains to HA molecules to form proteoglycans. The primary function of the link proteins is to bind collagen fibers to the cell membranes, which means that all cells have a mechanical contact via the extracellular matrix. Most of the chemical reactions in our bodies needs water! Water also gives volume and mechanical function to the tissue. Besides water in blood, lymph and digestive system, the water exists in the ground substance, outside the vascular system, and this is also called the interstitial fluid. It also enables the fibers to slide and glide between each other and HA gives the viscoelasticity. It is the environment where the cells exist, and it fills the spaces between fibers and cells. The ground substance is the “liquid” part with large molecules that bind volumes of water and is responsible for, among other things, the transport and exchange of ions, nutrients, waste substances and other molecules, between the blood capillaries and the cells.
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